tert-Butyl 3,4-dihydropyridine-1(2H)-carboxylate

tert-Butyl 3,4-dihydropyridine-1(2H)-carboxylate - Names and Identifiers

Name	N-Boc-3,4-dihydro-2H-pyridine
Synonyms	N-Boc-3,4-dihydro-2H-pyridine 1-N-BOC-3,4-DIHYDRO-2H-PYRIDINE tert-Butyl 3,4-dihydropyridine-1(2H)-carboxylate 3,4-DIHYDRO-2H-PYRIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS	131667-57-7

tert-Butyl 3,4-dihydropyridine-1(2H)-carboxylate - Physico-chemical Properties

Molecular Formula	C10H17NO2
Molar Mass	183.25
Density	0.988 g/mL at 25 °C
Boling Point	254 °C
Flash Point	107 °C
pKa	-0.56±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Refractive Index	n20/D1.477

tert-Butyl 3,4-dihydropyridine-1(2H)-carboxylate - Risk and Safety

Risk Codes	R25 - Toxic if swallowed R50 - Very Toxic to aquatic organisms
Safety Description	S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets.
UN IDs	UN 2810 6.1 / PGIII
WGK Germany	3

tert-Butyl 3,4-dihydropyridine-1(2H)-carboxylate - Upstream Downstream Industry

Raw Materials	N-Boc-piperidine-2-methanol N-BOC-1,2,3,6-TETRAHYDROPYRIDINE N-Boc-piperidine-3-methanol p-Trifluoromethoxy phenol 1-Boc-2-Methoxypiperidine tert-Butyl 4-(4-(trifluoromethoxy)phenoxy)piperidine-1-carboxylate 5-(BOC-AMINO)-1-PENTANOL N-BOC-2-HYDROXYPIPERIDINE 1-Boc-piperidine N-Boc-2-piperidone 1-Boc-4-methanesulfonyloxypiperidine 2-Piperidone Di-tert-butyl dicarbonate
Downstream Products	tert-butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydropyridine-1(2H)-carboxylate

tert-Butyl 3,4-dihydropyridine-1(2H)-carboxylate - Introduction

N-Boc-3,4-dihydro-2H-pyridine is an organic compound with the chemical formula C10H17NO2. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
N-Boc-3,4-dihydro-2H-pyridine is a white crystalline solid that is stable at room temperature. Its melting point is 54-56 degrees Celsius, its solubility is good, in some organic solvents such as methylene chloride and ethanol in high solubility.

Use:
N-Boc-3,4-dihydro-2H-pyridine is commonly used as an intermediate in organic synthesis. It can be used to synthesize a variety of drugs and bioactive molecules, such as anti-cancer agents and anti-anxiety drugs. In addition, it can also be used in the synthesis of pyridine and similar compounds.

Method:
N-Boc-3,4-dihydro-2H-pyridine can be prepared in a variety of ways. A common method is to react 3,4-dihydro-2H-pyridine with an N-protecting group (e. G. Tert-butyloxycarbonyl, Boc). Under certain reaction conditions, the N-Boc group is introduced on the nitrogen atom of 3,4-dihydro-2H-pyridine.

Safety Information:
N-Boc-3,4-dihydro-2H-pyridine is an organic compound. The following safety precautions should be paid attention to when using it: avoid inhaling its dust or gas, avoid contact with skin and eyes, wear appropriate protective gloves and goggles when using. At the same time, care should be taken to avoid contact with oxidants and strong acids during storage and handling to prevent dangerous reactions. In case of any accident during use, medical assistance should be sought immediately.

Last Update：2024-04-09 21:11:58